Oesophageal cancer: preoperative chemotherapy

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Oesophageal cancer: preoperative chemotherapy.

The optimal management of localised oesophageal cancer remains controversial. Indeed, currently utilised strategies are clearly unsatisfactory, given that most randomised trials report overall 5-year survivals of 20% or less for patients undergoing surgical resection. The rationale behind preoperative chemotherapy is two-fold: (i) to downstage or downsize the primary tumour in order to ensure c...

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Histopathological findings in oesophageal carcinoma with and without preoperative chemotherapy.

AIMS To investigate the pathological effects of preoperative chemotherapy on oesophageal carcinoma. METHODS Qualitative and quantitative changes in oesophageal carcinoma after preoperative chemotherapy were assessed by examination of biopsy specimens before treatment and resected specimens. RESULTS Of 13 patients with adenocarcinoma treated with 5-fluorouracil, adriamycin, and mitomycin (FA...

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Perioperative chemotherapy for gastro-oesophageal cancer.

In Western populations, cancers originating in the esophagus, gastroesophageal junction (gej), and stomach represent a major health problem and are considered highly lethal diseases, with an overall 5-year mortality rate that ranges from 17% to 27%1. Unfortunately, most of these patients present with latestage disease, when curative therapy is not possible1. Although surgical resection remains ...

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Bevacizumab with preoperative chemotherapy versus preoperative chemotherapy alone for colorectal cancer liver metastases

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Peri-operative chemotherapy in patients with oesophageal and gastro-oesophageal junction cancer - three years of experience.

Peri-operative chemotherapy has been found to benefit patients with oesophageal and gastro-oesophageal junction adenocarcinoma. This study's aim was to evaluate the efficacy and tolerance of this treatment. The study included patients with carcinoma of the lower oesophagus and gastro-oesophageal junction in whom the disease was evaluated as potentially operable. Chemotherapy (CHT) consisted of ...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2004

ISSN: 0923-7534

DOI: 10.1093/annonc/mdh909